METATOOL OUTPUT Version 3.5 (28.03.2001) C:\METATOOL\META35~1.EXE

INPUT FILE: EXAMPLE15.TXT

INTERNAL METABOLITES: 26
REACTIONS: 11

  4 external H2O
  2 int      NH3
  2 int      S-Adenosyl-L-methionine
  2 int      S-adenosyl-L-homocysteine
  2 int      N-formimino-L-glutamate
  1 int      RCH2NH2
  1 int      O2
  1 int      RCHO
  1 int      H2O2
  1 int      carnosine
  1 int      anserine
  1 int      histamine
  1 int      Ntau-methylhistamine
  1 int      5-Formiminotetrahydrofolate
  1 int      L-glutamate
  1 int      tetrahydrofolate
  1 int      N-Acetyl-L-aspartate
  1 int      a_fatty_acid_anion
  1 int      L-aspartate
  1 int      4-Imidazolone-5-propanoate
  1 int      L-Tryptophan
  1 int      tryptamine
  1 int      CO2
  1 int      Urocanate
  1 int      4,5-dihydro-4-oxo-5-imidazolepropanoate
  1 int      L-Histidine
  1 int      urocanate
 27 metabolites,  34 is the summarized frequency

edges	frequency of nodes
  0	  0
  1	 22
  2	  4
  3	  0
  4	  1

STOICHIOMETRIC MATRIX
 
 matrix dimension r26 x c11
 0  0 -1  0  0  0  0  0  0  0  0 
 0  0 -1  0  0  0  0  0  0  0  0 
 0  0  1  0  0  0  0  0  0  0  0 
 0  1  1  0  0  0  0  0  0  0  0 
 0  0  1  0  0  0  0  0  0  0  0 
 0  0  0 -1 -1  0  0  0  0  0  0 
 0  0  0 -1  0  0  0  0  0  0  0 
 0  0  0  1  1  0  0  0  0  0  0 
 0  0  0  1  0  0  0  0  0  0  0 
 0  0  0  0 -1  0  0  0  0  0  0 
 0  0  0  0  1  0  0  0  0  0  0 
-1  0  0  0  0  0  0  0  0  0  0 
-1  0  0  0  0  0  0  0  0  0  0 
 1  0  0  0  0  0  0  0  0  0  0 
 1  0  0  0  0  0  0  1  0  0  0 
 0  0  0  0  0  0 -1  0  0  0  0 
 0  0  0  0  0  0  1  0  0  0  0 
 0  0  0  0  0  0  1  0  0  0  0 
 0  0  0  0  0  0  0 -1  0  0  0 
 0  0  0  0  0  0  0  0 -1  0  0 
 0  0  0  0  0  0  0  0  1  0  0 
 0  0  0  0  0  0  0  0  1  0  0 
 0  0  0  0  0  0  0  0  0 -1  0 
 0  0  0  0  0  0  0  0  0  1  0 
 0 -1  0  0  0  0  0  0  0  0  0 
 0  1  0  0  0  0  0  0  0  0  0 
The following line indicates reversible (0) and irreversible reactions (1)
 0  0  1  1  1  1  1  1  1  1  1 
rows and columns are sorted as declared in the inputfile

NOT BALANCED INTERNAL METABOLITES
RCH2NH2	O2	RCHO	H2O2	carnosine	anserine	histamine	Ntau-methylhistamine	5-Formiminotetrahydrofolate	L-glutamate	tetrahydrofolate	N-Acetyl-L-aspartate	a_fatty_acid_anion	L-aspartate	4-Imidazolone-5-propanoate	L-Tryptophan	tryptamine	CO2	Urocanate	4,5-dihydro-4-oxo-5-imidazolepropanoate	L-Histidine	urocanate	

KERNEL
 
 matrix dimension r2 x c11
 0  0  0  0  0  1  0  0  0  0  0 
 0  0  0  0  0  0  0  0  0  0  1 
11 reactions (columns) are sorted in the same order as in the ENZREV ENZIRREV section.

 enzymes

 1:	 2.1.2.5 irreversible
 2:	 4.3.1.3 irreversible

 overall reaction
 - not found -


The remaining overall reactions perform no net transformation of external metabolites.

SUBSETS OF REACTIONS
 
 matrix dimension r2 x c11
 0  0  0  0  0  1  0  0  0  0  0 
 0  0  0  0  0  0  0  0  0  0  1 
11 reactions (columns) are sorted in the same order as in the ENZREV ENZIRREV section.

 enzymes

 1:	 2.1.2.5 irreversible
 2:	 4.3.1.3 irreversible

 overall reaction
 - not found -


The remaining overall reactions perform no net transformation of external metabolites.

REDUCED SYSTEM with 26 branch point metabolites in 2 reactions (columns)
 
 matrix dimension r0 x c2
The following line indicates reversible (0) and irreversible reactions (1)
 1  1 

-> Branch metabolites are : 
met                 	cons	built	reactions

-> No branch metabolites are : 
met                 	cons	built	reactions
RCH2NH2             	1	0	1	i
O2                  	1	0	1	i
RCHO                	0	1	1	i
NH3                 	0	2	2	ir
H2O2                	0	1	1	i
S-Adenosyl-L-methionine	2	0	2	ii
carnosine           	1	0	1	i
S-adenosyl-L-homocysteine	0	2	2	ii
anserine            	0	1	1	i
histamine           	1	0	1	i
Ntau-methylhistamine	0	1	1	i
5-Formiminotetrahydrofolate	1	0	1	r
L-glutamate         	1	0	1	r
tetrahydrofolate    	0	1	1	r
N-formimino-L-glutamate	0	2	2	ri
N-Acetyl-L-aspartate	1	0	1	i
a_fatty_acid_anion  	0	1	1	i
L-aspartate         	0	1	1	i
4-Imidazolone-5-propanoate	1	0	1	i
L-Tryptophan        	1	0	1	i
tryptamine          	0	1	1	i
CO2                 	0	1	1	i
Urocanate           	1	0	1	i
4,5-dihydro-4-oxo-5-imidazolepropanoate	0	1	1	i
L-Histidine         	1	0	1	r
urocanate           	0	1	1	r

CONVEX BASIS
 
 matrix dimension r2 x c11
 0  0  0  0  0  1  0  0  0  0  0 
 0  0  0  0  0  0  0  0  0  0  1 

 enzymes

 1:	 2.1.2.5 irreversible
 2:	 4.3.1.3 irreversible

 overall reaction
 - not found -


The remaining overall reactions perform no net transformation of external metabolites.

CONSERVATION RELATIONS
 
 matrix dimension r17 x c26
 1 -1  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0 
 1  0  1  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0 
 1  0  0  0  1  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0 
 0  0  0  0  0  1  0  1  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0 
 0  0  0  0  0  0  1  0  1  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0 
 0  0  0  0  0  1 -1  0  0 -1  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0 
 0  0  0  0  0 -1  1  0  0  0 -1  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0 
 0  0  0  0  0  0  0  0  0  0  0  1 -1  0  0  0  0  0  0  0  0  0  0  0  0  0 
 0  0  0  0  0  0  0  0  0  0  0  1  0  1  0  0  0  0  0  0  0  0  0  0  0  0 
 0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  1  1  0  0  0  0  0  0  0  0  0 
 0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  1  0  1  0  0  0  0  0  0  0  0 
 0  0  0  0  0  0  0  0  0  0  0  1  0  0  1  0  0  0  1  0  0  0  0  0  0  0 
 0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  1  1  0  0  0  0  0 
 0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  1  0  1  0  0  0  0 
 0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  1  1  0  0 
 1  0  0  1  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  1  0 
 1  0  0  1  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0 -1 
 1 :	RCH2NH2 + O2 = const
 2 :	RCH2NH2 + RCHO = const
 3 :	RCH2NH2 + H2O2 = const
 4 :	S-Adenosyl-L-methionine + S-adenosyl-L-homocysteine = const
 5 :	carnosine + anserine = const
 6 :	S-Adenosyl-L-methionine + carnosine + histamine = const
 7 :	S-Adenosyl-L-methionine + carnosine + Ntau-methylhistamine = const
 8 :	5-Formiminotetrahydrofolate + L-glutamate = const
 9 :	5-Formiminotetrahydrofolate + tetrahydrofolate = const
10 :	N-Acetyl-L-aspartate + a_fatty_acid_anion = const
11 :	N-Acetyl-L-aspartate + L-aspartate = const
12 :	5-Formiminotetrahydrofolate + N-formimino-L-glutamate + 4-Imidazolone-5-propanoate = const
13 :	L-Tryptophan + tryptamine = const
14 :	L-Tryptophan + CO2 = const
15 :	Urocanate + 4,5-dihydro-4-oxo-5-imidazolepropanoate = const
16 :	RCH2NH2 + NH3 + L-Histidine = const
17 :	RCH2NH2 + NH3 + urocanate = const

ELEMENTARY MODES
 
 matrix dimension r2 x c11
 0  0  0  0  0  1  0  0  0  0  0 
 0  0  0  0  0  0  0  0  0  0  1 
11 reactions (columns) are sorted in the same order as in the ENZREV ENZIRREV section.

 enzymes

 1:	 2.1.2.5 irreversible
 2:	 4.3.1.3 irreversible

 overall reaction
 - not found -


The remaining overall reactions perform no net transformation of external metabolites.

The elementary modes ARE EQUAL to convex basis.
