LocusLink Report
Description: LocusLink provides a single point-of-access for information about genes including sequences, nomenclature, map information, and links to related resources such as OMIM, GDB, HGMD, dbSNP, publications, and UniGene.

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LocusLink Home Kit Index: Top of Page Nomenclature Overview Function Relationships Map RefSeq GenBank Links LocusLink: Collaborators Download FAQ Help Statistics RefSeq: About Download FAQ Statistics |  | View One of 1 Loci
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Click to Display mRNA-Genomic Alignments (spanning 81484 bps)
| Mus musculus Official Gene Symbol and Name (MGI)
| Kit: kit oncogene
| LocusID: 16590
Overview | ?
| RefSeq Summary: The c-Kit proto-oncogene is the cellular homolog of the transforming gene of a feline retrovirus (v-Kit). The c-kit protein includes characteristics of a protein kinase transmembrane receptor.
| Locus Type: | gene with protein product, function known or inferred
| Product: | c-kit
| Alternate Symbols: | W, Bs, Fdc, Ssm, CD117, c-KIT, belly-spot
| Alias: | dominant spotting spotted sterile male Steel Factor Receptor Dominant white spotting c-kit proto-oncogene protein
Function | Submit GeneRIF | (All Pubs) | ?
| GeneRIF: Gene References into Function:
| 11964302 | Critical roles of c-Kit tyrosine residues 567 and 719 in stem cell factor-induced chemotaxis

| Gene OntologyTM:
| Term | Evidence | Source | Pub
| membrane | IEA | MGD |
| ATP binding | IEA | MGD |
| transferase | IEA | MGD |
| intracellular | IEA | MGD |
| protein kinase | IEA | MGD |
| protein tyrosine kinase | IEA | MGD |
| regulation of cell cycle | IEA | MGD |
| integral membrane protein | IEA | MGD |
| cell growth and/or maintenance | IEA | MGD |
| protein amino acid phosphorylation | IEA | MGD |
| transmembrane receptor protein tyrosine kinase | IEA | MGD |
| transmembrane receptor protein tyrosine kinase signaling pathway | IEA | MGD |

Relationships | ?
| Human Homology Maps: |  |  |  |
| NCBI vs. MGD |  | 4q11-q12 | KIT | Mm Hs
| UCSC vs. MGD |  | 4q11-q12 | KIT | Mm Hs
| NCBI vs. EST-based RH Map |  | 4q11-q12 | X06182 | Mm Hs
| UCSC vs. EST-based RH Map |  | 4q11-q12 | X06182 | Mm Hs
| UCSC vs. Hudson et al. |  | 4q11-q12 | AW263947 | Mm Hs
Map Information | ?
| Chromosome: | 5 |  |  | mv
| Cytogenetic: | 5 |  | RefSeq |
| Genetic: | 5 42.0 cM |  | MGD |
| Markers: | Chr. 5 | 3714 |  |
|  | Chr. 5 | Y00864 |  |
NCBI Reference Sequences (RefSeq) | ?
Category: REVIEWED
| mRNA: | NM_021099 |  |
| Protein: | NP_066922 c-kit | BL
| Domains: | Immunoglobulin | score: 125 |
|  | Immunoglobulin domain | score: 94 |
|  | Protein kinase domain | score: 198 |
|  | Immunoglobulin C-2 Type | score: 83 |
|  | Tyrosine kinase, catalytic domain | score: 610 |
|  | Serine/Threonine protein kinases, catalytic domain | score: 159 |
| Strain | BALB/c |  |
| GenBank Source: | AW741410,Y00864 |  |

Category: NCBI Genome Annotation

| Genomic Contig: | NW_000230 |  | gb sv mv ev mm
| Strain | C57BL/6J |  |
| Annotated transcripts/proteins for this locus:
--- | ---
| Evidence: | supported by alignment with both mRNA and ESTs (51) |  |
| Model mRNA: | XM_132123 |  |
| Model Protein: | XP_132123 |  | BL
| Domains: | Immunoglobulin | score: 125 |
|  | Immunoglobulin domain | score: 94 |
|  | Protein kinase domain | score: 402 |
|  | Immunoglobulin C-2 Type | score: 83 |
|  | Tyrosine kinase, catalytic domain | score: 616 |
|  | Serine/Threonine protein kinases, catalytic domain | score: 308 |

GenBank Sequences | ?

| Nucleotide | Type | Protein | Strain |
| L11358 | g | AAA37420 | BALB/c | BL
| X65998 | g | CAA46799 | ICR | BL
|  |  | CAA46800 |  | BL
| AW741410 | m |  |  |
| X65997 | m | CAA46798 | ICR | BL
| Y00864 | m | CAA68772 | BALB/c | BL

Additional Links | ?

| UniGene: Mm.4394

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